Spectroscopic insights on the interaction between 4-(3,4 dimethoxyphenyl)-6-hydroxy-2- methylpyrimidine-5-carbonitrile and tryptophan.
نویسندگان
چکیده
منابع مشابه
Spectrophotometric Determination of 4-Hydroxy-2-mercapto-6-methylpyrimidine Based on Aggregation of Colloidal Gold Nanoparticles
We report herein the development of a highly sensitive colorimetric method for the detection of 4-hydroxy-2-mercapto-6-methylpyrimidine (MTU) which acts as an anti-thyroid drug utilizing citrate capped gold nanoparticles (Au-NPs). This thiol-containing molecule exhibits intriguing affinity with Au-NPs. The reactivity involves the displacement of the citrate shell by the thiolate shell followed ...
متن کاملHistological investigations on the liver-disturbing action of 2-methyl-4-amino-5-hydroxy-methylpyrimidine.
Abderhalden (1) injected the pyrimidine and thiazole moieties of thiamine in mice and rats with the object of investigating the biosynthesis of thiamine and observed the induction of running fits. Its cause was further proved to be the pyrimidine moiety, i.e., 2-methyl-4-amino-5-hydroxymethylpyrimidine (OMP). Makino and Sasaki (2) reported the induction of running fits after in jecting this com...
متن کامل2-Benzylsulfanyl-4-[(4-methylphenyl)sulfanyl]-6-pentylpyrimidine-5-carbonitrile
In the title compound, C(24)H(25)N(3)S(2), the S-bound benzene rings have orthogonal [dihedral angle = 85.31 (9)°] and splayed [67.92 (11)°] orientations with respect to the pyrimidine ring; the dihedral angle between the benzene rings is 48.18 (12)°. The pentyl group has an extended all-trans conformation and lies to one side of the pyrimidine ring [the N(py)-C(py)-C(p)-C(p) torsion angle = -8...
متن کاملspectrophotometric determination of 4-hydroxy-2-mercapto-6-methylpyrimidine based on aggregation of colloidal gold nanoparticles
we report herein the development of a highly sensitive colorimetric method for the detection of 4-hydroxy-2-mercapto-6-methylpyrimidine (mtu) which acts as an anti-thyroid drug utilizing citrate capped gold nanoparticles (au-nps). this thiol-containing molecule exhibits intriguing affinity with au-nps. the reactivity involves the displacement of the citrate shell by the thiolate shell followed ...
متن کامل2-Benzylsulfanyl-4-pentyl-6-(phenylsulfanyl)pyrimidine-5-carbonitrile
In the title pyrimidine derivative, C(23)H(23)N(3)S(2), the phenyl-sulfanyl and benzyl-sulfanyl benzene rings are orientated away from the carbonitrile group and are twisted out of the plane of the central ring with dihedral angles of 77.66 (6) and 64.73 (5)°, respectively. The n-pentyl group has an extended trans conformation. In the crystal, supra-molecular layers in the ab plane are sustaine...
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ژورنال
عنوان ژورنال: Journal of Current Pharma Research
سال: 2019
ISSN: 2230-7834,2230-7842
DOI: 10.33786/jcpr.2019.v09i03.013